Denigma: Factor

C47D12.2

Symbol: C47D12.2
Name: TRRAP-like (transcription/transformation domain-associated protein)
Alias: hypothetical protein;WBGENE00008136
Entrez gene ID: 174789
Ensembl gene ID: C47D12.2
Species: Worm (Taxid: 6239)

Functional description:
Protein C47D12.2; Protein C47D12.2 [Source:UniProtKB/TrEMBL;Acc:Q18668] [Ensembl]; C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays [WormBase]

Observation:

C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747].

Interventions:

C47D12.2 RNAi +5.5% +8.7%

Assays: Organismal Lifespan
Mean: +6
Maximum: +9

Classification:

Gerontogene

Positive Gerontogene

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge