rnr-2

Symbol: rnr-2
Name: RiboNucleotide Reductase
Alias: RiboNucleotide Reductase family member (rnr-2);WBGENE00004392
Entrez gene ID: 175525
Ensembl gene ID: C03C10.3
Species: Worm (Taxid: 6239)

Functional description:
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [UniProt]

Observation:

rnr-2 RNAi in the adulthood extends mean and maximum lifespan by 14 and 22%, respectively [23144747].



Interventions:
  • rnr-2 RNAi +14.2% +21.7%

  • Assays: Organismal Lifespan
    Mean: +14.2
    Maximum: +21.7

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RRM2 (9606)
  • RRM2 (9615)
  • RRM2 (9913)
  • Rrm2 (10090)
  • Rrm2 (10116)
  • RRM2 (9031)
  • RnrS (7227)
  • AgaP_AGAP006818 (7165)
  • rnr-2 (6239)
  • suc22 (4896)
  • RNR2 (4932)
  • KLLA0F15103g (28985)
  • AGOS_AAL136C (33169)
  • GeneID:2684563 (148305)
  • NCU07887 (5141)
  • RNR2A (3702)



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