Denigma: Factor

lin-5

Symbol: lin-5
Name: abnormal cell LINeage
Alias: abnormal cell LINeage family member (lin-5);WBGENE00002994
Entrez gene ID: 174267
Ensembl gene ID: T09A5.10
Species: Worm (Taxid: 6239)

Functional description:
Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division. [UniProt]

Observation:

lin-5 RNAi in the adulthood extends mean and maximum lifespan by 16 and 9% [23144747].

Interventions:

lin-5 RNAi +16.4% +8.7%

Assays: Organismal Lifespan
Mean: +16.4
Maximum: +8.7

Classification:

Gerontogene

Positive Gerontogene

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge