aps-1

Symbol: aps-1
Name: AdaPtin, Small chain (clathrin associated complex) 1
Alias: AdaPtin;Small chain (clathrin associated complex) family member (aps-1);WBGENE00000159
Entrez gene ID: 178989
Ensembl gene ID: F29G9.3
Species: Worm (Taxid: 6239)

Functional description:
Protein APS-1; AdaPtin, Small chain (clathrin associated complex) family member (aps-1) [Source:RefSeq peptide;Acc:NP_504559] [Ensembl]; aps-1 encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1). [WormBase]

Observation:

aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747].



Interventions:
  • aps-1 RNAi +7.9% 0%

  • Assays: Organismal Lifespan
    Mean: +7.9
    Maximum: 0

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AP1S2 (9606)
  • AP1S2 (9598)
  • AP1S2 (9615)
  • AP1S2 (9913)
  • Ap1s2 (10090)
  • Ap1s2 (10116)
  • AP1S2 (9031)
  • ap1s2 (7955)
  • AP-1sigma (7227)
  • AgaP_AGAP004283 (7165)
  • aps-1 (6239)
  • SPAP27G11.06c (4896)
  • APS1 (4932)
  • KLLA0F22814g (28985)
  • AGOS_AFR124W (33169)
  • GeneID:2679123 (148305)
  • NCU10618 (5141)
  • AT4G35410 (3702)
  • AP19 (3702)
  • Os03g0783700 (4530)
  • PF11_0187 (5833)



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