Denigma

aph-2

Symbol: aph-2
Name: Anterior PHarynx defective
Alias: Anterior PHarynx defective family member (aph-2);WBGENE00000148
Entrez gene ID: 172905
Ensembl gene ID: ZC434.6
Species: Worm (Taxid: 6239)

Functional description:
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. [UniProt]

Observation:

aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators].



Interventions:
  • aph-2 RNAi

    • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • NCSTN (9606)
  • NCSTN (9598)
  • NCSTN (9615)
  • NCSTN (9913)
  • Ncstn (10090)
  • Ncstn (10116)
  • NCSTN (9031)
  • ncstn (7955)
  • nct (7227)
  • AgaP_AGAP001734 (7165)
  • aph-2 (6239)
  • AT3G52640 (3702)
  • Os02g0736500 (4530)



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