|
Symbol: asb-1 Name: ATP Synthase B homolog Alias: ATP Synthase B homolog family member (asb-1);WBGENE00000206 Entrez gene ID: 175605 Ensembl gene ID: F35G12.10 Species: Worm (Taxid: 6239) Functional description: Protein ASB-1; ATP Synthase B homolog family member (asb-1) [Source:RefSeq peptide;Acc:NP_497938] [Ensembl]; asb-1 encodes the B subunit of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V) that is closely similar to its paralog ASB-2; asb-1 activity is required for embryonic viability and for normal proliferation of germline cells, specifically their progression to meiosis; in addition, asb-1 is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; expression of asb-1 mRNA is enriched in the germline and an ASB-1::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons. The sterility of asb-1(RNAi) animals is variable; in one instance, an enlarged gonad contains densely packed nuclei in the distal portion (probably due to overproliferation), with infrequent transition zone nuclei, and possible ectopic mitotic nuclei in the proximal gonad. ASB-1 has 71% identity to ASB-2 (216/303 residues). [WormBase] Observation: asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. Interventions: Assays: Organismal Lifespan Mean: +6.4 Maximum: 0 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
Comment on This Data Unit