Denigma: Factor

rps-12

Symbol: rps-12
Name: Ribosomal Protein, Small subunit
Alias: Ribosomal Protein;Small subunit family member (rps-12);WBGENE00004481
Entrez gene ID: 175786
Ensembl gene ID: F54E7.2
Species: Worm (Taxid: 6239)

Functional description:
Ribosomal Protein, Small subunit; Protein RPS-12; 40S ribosomal protein S12 [Source:UniProtKB/Swiss-Prot;Acc:P49196] [Ensembl]; rps-12 encodes a small ribosomal subunit S12 protein; by homology, RPS-12 is predicted to function in protein biosynthesis; in C. elegans, RPS-12 activity is required for embryonic and germline development, normal movement, and the overall health of the animal. [WormBase]

Observation:

rps-12 RNAi in the adulthood extends mean and maximum lifespan by 12 and 22%, respectively [23144747].

Interventions:

rps-12 RNAi +11.6% +21.7%

Assays: Organismal Lifespan
Mean: +11.6
Maximum: +21.7

Classification:

Gerontogene

Positive Gerontogene

References:

23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.

Aging Relevance Analysis/Source:

GenAge