dcn-1

Symbol: dcn-1
Name: Defective in Cullin Neddylation
Alias: WBGene00010428
Entrez gene ID: 175556
Ensembl gene ID: H38K22.2
Species: Worm (Taxid: 6239)

Functional description:
Required for neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8- charged E2 enzyme to the cullin component of SCF-type complexes. [UniProt]

Observation:

snap-1 RNAi in the adulthood extends the lifespan [New longevity regulators]



Interventions:
  • dcn-1 RNAi

  • Assays: Organismal Lifespan

    Classification:

    Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • DCUN1D2 (9606)
  • DCUN1D2 (9598)
  • DCUN1D2 (9615)
  • Dcun1d2 (10090)
  • Dcun1d2 (10116)
  • DCUN1D2 (9031)
  • rp42-pen (7955)
  • LOC100333691 (7955)
  • dcn-1 (6239)
  • AT3G12760 (3702)
  • Os06g0233400 (4530)



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