sptf-3

Symbol: sptf-3
Name: Specificity Protein Transcription Factor 3
Entrez gene ID: 189783
Ensembl gene ID: Y40B1A.4
Species: Worm (Taxid: 6239)

Functional description:
Protein SPTF-3; Specificity Protein) Transcription Factor family member (sptf-3) [Source:RefSeq peptide;Acc:NP_493353] [Ensembl]

Observation:

RNAi against sptf-3 decreases mean and maximum lifespan by 20 - 28% and 28%, respectively. sptf-3 RNAi in the adulthood decreases the mean and maximum lifespan by 23 and 37% [23144747]. sptf-3 overexpression extends lifespan [18059442].



Interventions:
  • sptf-3 RNAi -20 to -28% -28 to -37%
  • sptf-3 Overexpression

  • Assays: Organismal Lifespan
    Mean: -20 to -23
    Maximum: -28 to -37

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 18059442: A modular network model of aging.
  • 23144747: Prediction of C. elegans Longevity Genes by Human and Worm Longevity Networks.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SP4 (9606)
  • SP4 (9598)
  • SP4 (9615)
  • Sp4 (10090)
  • Sp4 (10116)
  • SP4 (9031)
  • sp4 (7955)
  • CG5669 (7227)
  • AgaP_AGAP004438 (7165)
  • sptf-3 (6239)

  • Note: PAS and NAS as well as PG!

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