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Symbol: snap-29 Name: SNAP (Soluble NSF Attachment Protein) homolog 29 Alias: phi-28 Entrez gene ID: 176233 Ensembl gene ID: K02D10.5 Species: Worm (Taxid: 6239) Functional description: Protein SNAP-29; Soluable nsf attachment protein 29 [Source:UniProtKB/Swiss-Prot;Acc:P83351] [Ensembl]; snap-29 encodes one of the SNAP25-family of double SNARE-domain target-SNAREs orthologous to human synaptosomal-Associated protein (OMIM:604202); snap-29 is an essential gene important for development and cellular functions throughout the life cycle; SNAP-29 is required for secretion of many transmembrane cargo proteins of oocyte cells; loss of SNAP-29 leads to defects in ovulation and RNAi leads to defects in maturation of distal oocytes; SNAP-29 is involved in membrane transport; SNAP-29 regulates LIN-3/EGF secretion in the oocyte which is essential for ovulation; SNAP-29 is expressed in excretory canal, gland cells, hypodermis, vulva, coelomocyte, intestine, gonad sheath cells and some neurons. [WormBase] Observation: RNAi against snap-29 starting in the adulthood decreases mean and maximum lifespan by 49 and 72%, respectively [23144747]. Interventions: Assays: Organismal Lifespan Mean: -48.6 Maximum: -72.0 Classification: References: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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