HFI1

Symbol: HFI1
Name: Histone H2A Functional Interactor 1
Alias: ADA1;SUP110;SRM12;GAN1
Entrez gene ID: 855821
Ensembl gene ID: YPL254W
Species: Yeast (Taxid: 4932)

Functional description:
Hfi1p; Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions [Source:SGD;Acc:S000006175] [Ensembl]

Observation:

ADA1 deletion shortens replicative lifespan by approximately 80%. This is not a premature aging phenotype as ADA1 cells do not become prematurely sterile or shibit other biomarkers of aging. ADA1 mutants are temperature-sensitive and respiratory-deficent.



Assays: Replicative Lifespan

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • hfi1 (4896)
  • HFI1 (4932)
  • KLLA0B10351g (28985)
  • AGOS_AFL171W (33169)

  • Note: I have no access to the paper.

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