LCB4

Symbol: LCB4
Name: Long-Chain Base 4
Entrez gene ID: 854342
Ensembl gene ID: YOR171C
Species: Yeast (Taxid: 4932)

Functional description:
Lcb4p; Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes [Source:SGD;Acc:S000005697] [Ensembl]

Observation:

Deletion of LCB4 increases replicative lifespan and cancels out replicative lifespan extension of 0.5% glucose DR [18690010].



Interventions:
  • LCB4 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPAC4A8.07c (4896)
  • LCB5 (4932)
  • LCB4 (4932)
  • KLLA0F20504g (28985)
  • AGOS_AGR256W (33169)
  • GeneID:2675608 (148305)
  • NCU07937 (5141)

  • Orthologs
  • SPHK2 (9606)
  • Sphk1 (10116)
  • CG31873 (7227)
  • SPHK2 (9544)
  • Agk (10090)
  • AGK (9606)
  • SPHK1 (9606)
  • sphk-1 (6239)
  • Sphk2 (10090)
  • AGK (9544)
  • Sk2 (7227)
  • Sk1 (7227)
  • Sphk1 (10090)
  • Agk (10116)
  • SPAC4A8.07c (4896)
  • Sphk2 (10116)
  • F52C9.3 (6239)
  • LOC710441 (9544)
  • SPHK2 (9606)
  • Sphk1 (10116)
  • LCB5 (4932)
  • CG31873 (7227)
  • SPHK2 (9544)
  • Agk (10090)
  • AGK (9606)
  • SPHK1 (9606)
  • sphk-1 (6239)
  • Sphk2 (10090)
  • AGK (9544)
  • Sk2 (7227)
  • Sk1 (7227)
  • Sphk1 (10090)
  • Agk (10116)
  • SPAC4A8.07c (4896)
  • Sphk2 (10116)
  • F52C9.3 (6239)
  • LOC710441 (9544)



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