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Symbol: D2030.4 Entrez gene ID: 172513 Ensembl gene ID: D2030.4 Species: Worm (Taxid: 6239) Functional description: NADH coQ oxidoreductaseB18 (complex I); Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). [UniProt] Observation: RNAi against D2030.4 prolongs mean and maximum lifespan by 43% and 50%, respectively. Lifespan extension by RNAi of D2030.4 is not suppressed by daf-16. D2030.4 RNAi animals have lower ATP content and oxygen consumption [12447374]. Interventions: Assays: Organismal Lifespan Mean: +43 Maximum: +50 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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