Denigma: Factor

atf1

Symbol: atf1
Name: activating transcription factor 1
Alias: mts1; sss1; gad7; SPNCRNA.353; SPNG1409
Entrez gene ID: 2540329
Ensembl gene ID: SPBC29B5.01
Species: (Taxid: 4896)

Functional description:
transcription factor, Atf-CREB family Atf1; protein disulfide isomerase family A, member 6 [Source:HGNC Symbol;Acc:30168] [Ensembl]

Observation:

Activation of transcription factor Atf1 by Sty1 is required for chronological lifespan extension and enhanced heat stress resistance by DR. Deleting atf1 cancels out DR-mediated chronological lifespan extension and enhanced heat stress resistance. Overexpressing atf1 is not sufficient to promote chronological lifespan extension in cells lacking sty1 [20075862].

Interventions:

atf1 deletion

atf1 overexpression

Assays: Chronological Lifespan

Classification:

DR-Essential

Aging Relevance Analysis/Source:

GenAge