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Symbol: rab-10 Name: RAB family Entrez gene ID: 266836 Ensembl gene ID: T23H2.5 Species: Worm (Taxid: 6239) Functional description: Protein RAB-10; RAB family member (rab-10) [Source:RefSeq peptide;Acc:NP_491857] [Ensembl]; rab-10 encodes a Rab-like GTPase that is a member of the Ras superfamily of small GTPases; RAB-10 is required, upstream of RME-1, for basolateral endocytic recycling in the intestine, but not in oocytes or coelomocytes; RAB-10 is also required for GLR-1 receptor recycling in interneurons; a RAB-10::GFP fusion protein is widely expressed and in the intestine, localizes to early endosomes and the Golgi. [WormBase] Observation: rab-10 RNA interference significantly extends lifespan of wild-type by 14 - 16%, of daf-16 mutants by 47%, and of daf-2 by 46%, but fails to significantly further extend lifespan of eat-2 mutants. rab-10 RNAi does not affect pumping, but similar to DR reduces and delays reproduction as well as cause a slender appearance. rab-10 mRNA is 2-fold downregulated in response to DR [16103914]. rab-10 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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