vps-34

Symbol: vps-34
Name: related to yeast Vacuolar Protein Sorting factor 34
Entrez gene ID: 172280
Ensembl gene ID: B0025.1
Species: Worm (Taxid: 6239)

Functional description:
Protein VPS-34; related to yeast Vacuolar Protein Sorting factor family member (vps-34) [Source:RefSeq peptide;Acc:NP_491741] [Ensembl]; vps-34 encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development; in C. elegans, vps-34 is required for vesicular trafficking, including endocytosis, apoptotic cell clearance, and autophagy. Inactivation of vps-34 by RNAi induces a defect in encocytotic uptake of secreted GFP into coelomocytes from pseudocoelomic fluid. In addition, vps-34(RNAi) mutants exhibit slower growth than normal. vps-34 is ubiquitously expressed in all tissues and developmental stages. VPS-34 protein accumulates in a perinuclear region of the cell. vps-34(h510) mutants display an expansion of the outer nuclear membrane, and VPS-34 is genetically required for the secretion and localization of the LDL receptor LRP-1 at the apical surface of the hypodermal syncytium. Phosphatidylinositol 3-phosphate (PtdIns 3-P) produced by VPS-34 associates with several intracellular membranes and periphereal vesicles, including endocytic vesicles. These data are consistent with the hypothesis that VPS-34 is generally required for membrane transport from the outer nuclear membrane towards the cell periphery. [WormBase]

Observation:

vps-34 RNAi does not significantly change lifespan of wild-type, but cancels out the lifespan extension effect of eat-2 mutation [18282106].



Assays: Organismal Lifespan

Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PIK3C3 (9606)
  • PIK3C3 (9598)
  • PIK3C3 (9615)
  • PIK3C3 (9913)
  • Pik3c3 (10090)
  • Pik3c3 (10116)
  • pik3c3 (7955)
  • Pi3K59F (7227)
  • AgaP_AGAP010273 (7165)
  • vps-34 (6239)
  • pik3 (4896)
  • VPS34 (4932)
  • KLLA0D18645g (28985)
  • AGOS_AGL113C (33169)
  • GeneID:2682622 (148305)
  • NCU00656 (5141)
  • ATVPS34 (3702)
  • Os05g0180600 (4530)

  • Orthologs
  • Pi3K59F (7227)
  • PIK3C3 (9606)
  • Pik3c3 (10090)
  • pik3 (4896)
  • PIK3C3 (9544)
  • Pik3c3 (10116)
  • VPS34 (4932)
  • age-1 (6239)
  • Pi3K59F (7227)
  • PIK3C3 (9606)
  • age-1 (6239)
  • Pik3c3 (10090)
  • F39B1.1 (6239)
  • pik3 (4896)
  • PIK3C3 (9544)
  • Pik3c3 (10116)
  • VPS34 (4932)



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