Symbol: vps-34 Name: related to yeast Vacuolar Protein Sorting factor 34 Entrez gene ID: 172280 Ensembl gene ID: B0025.1 Species: Worm (Taxid: 6239) Functional description: Protein VPS-34; related to yeast Vacuolar Protein Sorting factor family member (vps-34) [Source:RefSeq peptide;Acc:NP_491741] [Ensembl]; vps-34 encodes an ortholog of the phosphoinositide 3-kinase VPS34 in S. cerevisiae, a protein that regulates multiple steps in endocytosis, and that is required for growth at normal rates during development; in C. elegans, vps-34 is required for vesicular trafficking, including endocytosis, apoptotic cell clearance, and autophagy. Inactivation of vps-34 by RNAi induces a defect in encocytotic uptake of secreted GFP into coelomocytes from pseudocoelomic fluid. In addition, vps-34(RNAi) mutants exhibit slower growth than normal. vps-34 is ubiquitously expressed in all tissues and developmental stages. VPS-34 protein accumulates in a perinuclear region of the cell. vps-34(h510) mutants display an expansion of the outer nuclear membrane, and VPS-34 is genetically required for the secretion and localization of the LDL receptor LRP-1 at the apical surface of the hypodermal syncytium. Phosphatidylinositol 3-phosphate (PtdIns 3-P) produced by VPS-34 associates with several intracellular membranes and periphereal vesicles, including endocytic vesicles. These data are consistent with the hypothesis that VPS-34 is generally required for membrane transport from the outer nuclear membrane towards the cell periphery. [WormBase] Observation: vps-34 RNAi does not significantly change lifespan of wild-type, but cancels out the lifespan extension effect of eat-2 mutation [18282106]. Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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