ubc-18

Symbol: ubc-18
Name: UBiquitin Conjugating enzyme 18
Entrez gene ID: 175985
Ensembl gene ID: R01H2.6
Species: Worm (Taxid: 6239)

Functional description:
Protein UBC-18; UBiquitin Conjugating enzyme family member (ubc-18) [Source:RefSeq peptide;Acc:NP_498541] [Ensembl]; ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known. [WormBase]

Observation:

ubc-18 overexpression is unable to extend lifespan (possibly, UBC-18 is not limiting for WWP-1 function in lifespan). Loss of ubc-18 function by mutation or RNAi reduces lifespan at 25 degree Celsius, but only slightly at 20 degree Celsius. RNAi depletion of ubc-18 completely suppresses increased longevity of eat-2 mutants. RNAi depletion of ubc-18 has no effect on long lifespan of isp-1 or daf-2 mutants. Combined knockdown of wwp-1 and ubc-18 by RNAi does not shorten lifespan any further than RNAi of either single gene. Knockdown of ubc-18 suppresses extended lifespan of wwp-1 overexpression [19553937].



Interventions:
  • ubc-18 overexpression
  • ubc-18 mutation
  • ubc-18 RNAi

  • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • UBE2L3 (9606)
  • UBE2L3 (9598)
  • UBE2L3 (9615)
  • UBE2L3 (9913)
  • Ube2l3 (10090)
  • Ube2l3 (10116)
  • UBE2L3 (9031)
  • ube2l3a (7955)
  • LOC100330447 (7955)
  • UbcD10 (7227)
  • AgaP_AGAP001056 (7165)
  • ubc-18 (6239)

  • Orthologs
  • UBE2L3 (9606)
  • CG10862 (7227)
  • UbcD10 (7227)
  • UBE2L3 (9544)
  • Ube2l3 (10090)
  • Ubc84D (7227)
  • LOC712771 (9544)
  • Ube2l3 (10116)
  • CG2574 (7227)
  • CG17030 (7227)
  • UBE2L3 (9606)
  • CG10862 (7227)
  • ubc-24 (6239)
  • ubc-16 (6239)
  • UbcD10 (7227)
  • UBE2L3 (9544)
  • Ube2l3 (10090)
  • Ubc84D (7227)
  • LOC712771 (9544)
  • Ube2l3 (10116)
  • CG2574 (7227)
  • CG17030 (7227)



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