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Symbol: cup-5 Name: Coelomocyte UPtake defective 5 Entrez gene ID: 176074 Ensembl gene ID: R13A5.1 Species: Worm (Taxid: 6239) Functional description: Protein CUP-5; Coelomocyte UPtake defective family member (cup-5) [Source:RefSeq peptide;Acc:NP_498664] [Ensembl]; The cup-5 gene encodes an ortholog of the human mucolipin 1 gene; cup-5 is required for viability, endo-lysosomal transport and the normal degradation of lysosomes; cup-5 mutants also show increased cell death, which might be a secondary consequence of lysosomal dysfunction; the inactivation of mrp-4 which is a ABCC transporter rescues most of the defects in cup-5 mutants, suggesting that the accumulation of ABC transporters in the absence of cup-5, may contribute to the lysosomal defects; cup-5 localizes to lysosomes. [WormBase] Observation: cup-5 RNAi significantly decreases lifespan of eat-2 specifically, whereas lifespan of age-1 or clk-1 mutants are not affected [19783783]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Orthologs Edit \ Update (Admin) | Delete |
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