Denigma

phb-1

Symbol: phb-1
Name: mitochondrial ProHiBitin complex 1
Entrez gene ID: 171768
Ensembl gene ID: Y37E3.9
Species: Worm (Taxid: 6239)

Functional description:
PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. [UniProt]

Observation:

phb-1 RNAi shortens lifespan of wild-type, aak-2, cep-1 (p53) and jnk-1 mutants, but increases lifespan of daf-2, daf-7, daf-4, daf-11, gas-1, mev-1, isp-1, clk-1, nhr-49, fat-7 and gld-1 mutants. daf-16 mutation fully suppressed the exceptional long-lifespan of prohibitin-depleted (via RNAi) daf-2 mutants [19812672].



Interventions:
  • phb-1 RNAi

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • PHB (9606)
  • PHB (9598)
  • PHB (9615)
  • PHB (9913)
  • Phb (10090)
  • LOC688815 (10116)
  • PHB (9031)
  • phb (7955)
  • LOC100334735 (7955)
  • l(2)37Cc (7227)
  • AgaP_AGAP009323 (7165)
  • phb-1 (6239)
  • SPAC1782.06c (4896)
  • PHB1 (4932)
  • KLLA0D16302g (28985)
  • AGOS_AFR313C (33169)
  • GeneID:2683971 (148305)
  • NCU08946 (5141)
  • ATPHB4 (3702)
  • ATPHB3 (3702)
  • Os02g0580500 (4530)
  • Os04g0462900 (4530)
  • PF08_0006 (5833)

    • Orthologs
  • PHB (9544)
  • l(2)37Cc (7227)
  • LOC715350 (9544)
  • SPAC1782.06c (4896)
  • PHB1 (4932)
  • LOC688815 (10116)
  • RGD1566197 (10116)
  • Phb (10090)
  • PHB (9606)
  • PHB (9544)
  • l(2)37Cc (7227)
  • LOC715350 (9544)
  • SPAC1782.06c (4896)
  • PHB1 (4932)
  • LOC688815 (10116)
  • RGD1566197 (10116)
  • Phb (10090)
  • PHB (9606)



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