YHB4

Symbol: YHB4
Name: Yeast HemogloBin-like protein 4
Alias: YHB4
Entrez gene ID: 853149
Ensembl gene ID: YGR234W
Species: Yeast (Taxid: 4932)

Functional description:
Yhb1p; Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses [Source:SGD;Acc:S000003466] [Ensembl]

Observation:

sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246].



Interventions:
  • YHB1 deletion
  • SFA1 YHB1 double mutation

  • Assays: Replicative Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPAC869.02c (4896)
  • YHB1 (4932)
  • KLLA0B14476g (28985)
  • GeneID:2674580 (148305)
  • NCU10051 (5141)

  • Orthologs
  • SPAC869.02c (4896)
  • SPAC869.02c (4896)



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