Symbol: YHB4 Name: Yeast HemogloBin-like protein 4 Alias: YHB4 Entrez gene ID: 853149 Ensembl gene ID: YGR234W Species: Yeast (Taxid: 4932) Functional description: Yhb1p; Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses [Source:SGD;Acc:S000003466] [Ensembl] Observation: sfa1;yhb1 double mutant cancels out the ability of moderate DR to extend replicative lifespan, but not chronological lifespan. Indicating that NO homeostasis during DR-induced replicative lifespan extension is crucial. Deleting YHB1 partially abolished DR-induced replicative lifespan extension, whereas deleting SFA1 alone had no effect. Yhb1 and Sfa1 may play redundant roles [21584246]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Orthologs Edit \ Update (Admin) | Delete |
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