OPT2

Symbol: OPT2
Name: OligoPeptide Transporter 2
Entrez gene ID: 856324
Ensembl gene ID: YPR194C
Species: Yeast (Taxid: 4932)

Functional description:
Opt2p; Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles [Source:SGD;Acc:S000006398] [Ensembl]

Observation:

OPT2 deletion increases mean and maximum replicative lifespan by 23 and 9%, respectively, and cancels out the lifespan-extending effect of DR [22912585].



Interventions:
  • OPT2 deletion +23% +9%

  • Assays: Replicative Lifespan
    Mean: +23
    Maximum: +9

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • OPT2 (4932)
  • AGOS_ADL399C (33169)
  • AGOS_ACL205C (33169)
  • NCU07894 (5141)

  • Orthologs
  • OPT1 (4932)



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