SLM4

Symbol: SLM4
Name: Synthetic Lethal with Mss4 4
Alias: EGO3; NIR1; GSE1
Entrez gene ID: 852369
Ensembl gene ID: YBR077C
Species: Yeast (Taxid: 4932)

Functional description:
Slm4p; Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 [Source:SGD;Acc:S000000281] [Ensembl]

Observation:

SLM4 deletion blocks replicative lifespan extension by moderate DR, but does affect lifespan on AL significantly [22912585].



Interventions:
  • SLM4 deletion +2% -10%

  • Assays: Replicative Lifespan

    Classification:
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SLM4 (4932)
  • AGOS_AGL204C (33169)



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