Denigma

IMD2

Symbol: IMD2
Name: IMP Dehydrogenase 2
Alias: PUR5
Entrez gene ID: 856626
Ensembl gene ID: YHR216W
Species: Yeast (Taxid: 4932)

Functional description:
Imd2p; Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio [Source:SGD;Acc:S000001259] [Ensembl]

Observation:

Deletion of IMD2 does non-significantly decrease mean replicative lifespan by 1% and non-significantly increased maximum replicative lifespan by 21% [20550517].



Interventions:
  • IMD2 deletion -1% +21%

    • Assays: Replicative Lifespan

    Classification:
  • Aging Associated
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • IMPDH1 (9606)
  • IMPDH1 (9615)
  • IMPDH1 (9913)
  • Impdh1 (10090)
  • Impdh1 (10116)
  • impdh1b (7955)
  • impdh1a (7955)
  • ras (7227)
  • AgaP_AGAP011133 (7165)
  • T22D1.3 (6239)
  • gua1 (4896)
  • IMD4 (4932)
  • IMD2 (4932)
  • IMD3 (4932)
  • KLLA0B05511g (28985)
  • AGOS_AER117W (33169)
  • GeneID:2676765 (148305)
  • NCU03117 (5141)
  • PFI1020c (5833)

    • Note: Is the maximumm lifespan extension really not significant?

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