Denigma

FCY1

Symbol: FCY1
Name: FluoroCYtosine resistance 1
Entrez gene ID: 856175
Ensembl gene ID: YPR062W
Species: Yeast (Taxid: 4932)

Functional description:
Fcy1p; Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) [Source:SGD;Acc:S000006266] [Ensembl]

Observation:

Deletion of FCY1 does non-significantly decrease mean and maximum replicative lifespan by 4% and 8%, respectively [20550517].



Interventions:
  • FCY1 deletion +4% +8%

    • Assays: Replicative Lifespan

    Classification:
  • Aging Associated
  • No Age Effect


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • FCY1 (4932)
  • KLLA0B08437g (28985)
  • NCU07413 (5141)

    • Note: Non-significantly decrease.

    Edit \ Update (Admin) | Delete

    Comment on This Data Unit