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Symbol: FKH2 Name: ForK head Homolog 2 Entrez gene ID: 855656 Ensembl gene ID: YNL068C Species: Yeast (Taxid: 4932) Functional description: Fkh2p; Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase [Source:SGD;Acc:S000005012] [Ensembl] Observation: Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in slight increased chronological and replicative lifespan as well as stress resistance [22438832]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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