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Symbol: exo-3 Name: EXOnuclease Entrez gene ID: 173069 Ensembl gene ID: R09B3.1 Species: Worm (Taxid: 6239) Functional description: Protein EXO-3; EXOnuclease family member (exo-3) [Source:RefSeq peptide;Acc:NP_001021584] [Ensembl]; exo-3 encodes an ortholog of human APEX/REF1 and rat apurinic/apyrimidinic endonuclease (AP endonuclease 1); EXO-3 is implicated in a DNA damage checkpoint pathway that affects embryonic and larval viability. [WormBase] Observation: exo-3 RNAi results in 3-fold increase in mitochondrial DNA deletion, 2-fold enhanced generation of reactive oxygene species, distortion of the structural intertiy of the nervous system, reduction of head motility by 43% and whole animal motility by 38% as well as a reduction of mean lifespan by 16% and maximum lifespan by 10% [20346071]. Assays: Mean: -16 Maximum: -10 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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