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Symbol: Rpn11 Alias: 37B;CG18174;Dmel\CG18174;DmS13;p37B;RPn11;RPN11;S13;yip5 Entrez gene ID: 33738 Ensembl gene ID: FBgn0028694 Species: Fly (Taxid: 7227) Functional description: Subunit of the 19S regulatory particle; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). [UniProt] Observation: Overexpression of Rpn11, enconding a subunit of the 19S regulatory particle, suppresses age-related reduction of the 26S proteasome activity and results in extension of mean and maximum lifespan by 35% and 11%, respectively, as well as suppression of the age-dependent accumulation of ubiqitinated proteins. Loss of function of Rpn11 causes early onset of reduced 26S protesamsoe activity and a premature age-dependent accumulation of ubiqitinated proteins as well as shortened mean and maximum lifespan by 55% and 58%, respectively, and enhanced neurodegenerative phenotype [19075009]. Assays: Mean: +35 Maximum: +11 Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Inparanoids Edit \ Update (Admin) | Delete |
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