cyc-1

Symbol: cyc-1
Name: Cytochrome c1
Entrez gene ID: 172582
Ensembl gene ID: C54G4.8
Species: Worm (Taxid: 6239)

Functional description:
Protein CYC-1; CYtochrome C family member (cyc-1) [Source:RefSeq peptide;Acc:NP_492207] [Ensembl]; cyc-1 encodes a component of complex III ( cytochrome c reductase) required for normal ATP production; reduction of ATP production by cyc-1(RNAi) decreases growth rate and body size, slows behavior, and increases lifespan; cyc-1 encodes a protein predicted by Eisenberg and coworkers, with 52% accuracy, to be mitochondrial [WormBase]

Observation:

RNA interference of cyc-1 results in a 45-87% increase in mean lifespan [16103914]. cyc-1 RNAi extends mean and maximum lifespan by 66 and 79%, respectively. RNAi of cyc-1 during larval stages is necessary and sufficient for lifespan extension, while RNAi of cyc-1 only during the adulthood fails to extend lifespan [12471266]. RNAi against cyc-1 increases mean and 75th %ile lifespan by 8-28 and 16-29%, respectively [22560223]. cyc-1 RNAi results in reduced pharyngeal pumping, defection, motility, ATP levels (by 60-80%), an body size. Mutation of daf-16 fails to prevent lifespan extenison by RNAi of cyc-1 and mutation of daf-2 further extends the lifespan of cyc-1 RNAi animals [12471266].



Interventions:
  • cyc-1 RNAi +8 to +87% +79%

  • Assays: Organismal Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CYC1 (9606)
  • CYC1 (9598)
  • LOC475121 (9615)
  • CYC1 (9913)
  • Cyc1 (10090)
  • Cyc1 (10116)
  • cyc1 (7955)
  • CG4769 (7227)
  • AgaP_AGAP006936 (7165)
  • cyc-1 (6239)
  • cyt1 (4896)
  • CYT1 (4932)
  • KLLA0F16555g (28985)
  • AGOS_ADR208W (33169)
  • GeneID:2676187 (148305)
  • NCU09816 (5141)
  • AT3G27240 (3702)
  • AT5G40810 (3702)
  • Os05g0301700 (4530)
  • Os01g0935700 (4530)
  • PF14_0597 (5833)

  • Orthologs
  • CYT1 (4932)
  • CYT1 (4932)
  • CYT1 (4932)



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