MOT2

Symbol: MOT2
Name: Modulator Of Transcription 2
Alias: NOT4;SIG1
Entrez gene ID: 856799
Ensembl gene ID: YER068W
Species: Yeast (Taxid: 4932)

Functional description:
Mot2p; Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p [Source:SGD;Acc:S000000870] [Ensembl]; Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications [SGD]

Observation:

Deletion of MOT2 increases mean chronological lifespan by 25 - 85% (25, 34, 41, 85) in diploid cells [21447998]



Assays:
Mean: +25-85

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MOT2 (4932)
  • KLLA0C08041g (28985)
  • AGOS_ADL064W (33169)



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