HOM6

Symbol: HOM6
Name: HOMoserine requiring 6
Entrez gene ID: 853604
Ensembl gene ID: YJR139C
Species: Yeast (Taxid: 4932)

Functional description:
Hom6p; Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions [Source:SGD;Acc:S000003900] [Ensembl]

Observation:

Deletion of HOM6 extends mean chronological lifespan by 75 - 256% (75, 159, 202, 256) in diploid cells [21447998].



Assays:
Mean: +75-256

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SPBC776.03 (4896)
  • HOM6 (4932)
  • KLLA0B03872g (28985)
  • AGOS_ABL080W (33169)
  • GeneID:5050609 (148305)
  • NCU03935 (5141)
  • AK-HSDH_I (3702)
  • Os08g0342400 (4530)
  • Os09g0294000 (4530)



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