ADE4

Symbol: ADE4
Name: ADEnine requiring 4
Entrez gene ID: 855346
Ensembl gene ID: YMR300C
Species: Yeast (Taxid: 4932)

Functional description:
Ade4p; Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000004915] [Ensembl]

Observation:

ade4 mutation extends chronological lifespan, but not replicative lifespan, and is non-additive with 0.5% glucose or amino-acid DR on chronological lifespan extension. ADE4 deletion in atg16 mutants results only in a partial extension of the chronological lifespan by 0.5% glucose DR [20421943].



Interventions:
  • ADE4 deletion

  • Assays: Chronological Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene
  • DR-Essential


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • PPAT (9606)
  • PPAT (9598)
  • PPAT (9615)
  • PPAT (9913)
  • Ppat (10090)
  • Ppat (10116)
  • PPAT (9031)
  • ppat (7955)
  • Prat (7227)
  • Prat2 (7227)
  • AgaP_AGAP000179 (7165)
  • Amidophosphoribosyltransferase (6239)
  • ade4 (4896)
  • ADE4 (4932)
  • KLLA0A10109g (28985)
  • AGOS_AGL334W (33169)
  • GeneID:2677934 (148305)
  • NCU04216 (5141)
  • ATASE3 (3702)
  • ATASE1 (3702)
  • ATASE2 (3702)

  • Orthologs
  • ade4 (4896)
  • Ppat (10090)
  • Ppat (10116)
  • LOC715692 (9544)
  • PPAT (9606)
  • Prat2 (7227)
  • Prat (7227)
  • PPAT (9544)
  • Amidophosphoribosylt (6239)
  • ade4 (4896)
  • Ppat (10090)
  • Ppat (10116)
  • LOC715692 (9544)
  • PPAT (9606)
  • Prat2 (7227)
  • Prat (7227)
  • PPAT (9544)
  • Amidophosphoribosylt (6239)



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