sm

Symbol: sm
Name: smooth
Alias: CG9218-PA;CG9218-PB;CG9218-PE;CG9218-PG;CG9218-PH;CG9218-PI;sm-PA;sm-PB;sm-PE;sm-PG;sm-PH;sm-PI
Entrez gene ID: 37254
Ensembl gene ID: FBgn0003435
Species: Fly (Taxid: 7227)

Functional description:
smooth; smooth [Source:FlyBase gene name;Acc:FBgn0003435] [Ensembl]; The gene smooth is referred to in FlyBase by the symbol Dmel\sm (CG9218, FBgn0003435). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: axon guidance; adult feeding behavior. 28 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; macrochaeta; abdominal sternite bristle; acrostichal bristle; scutellar bristle; microchaeta. It has 20 annotated transcripts and 20 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed in adult male stages. [FlyBase]

Observation:

Overexpression of sm in males increases mean and maximum lifespan by 29% and and 16%, respectively [22366109].



Interventions:
  • sm overexpression

  • Assays: Organismal Lifespan
    Mean: +29
    Median: +16

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • HNRNPL (9606)
  • HNRNPL (9598)
  • HNRNPL (9615)
  • HNRNPL (9913)
  • Hnrnpl (10090)
  • Hnrnpl (10116)
  • hnrpl (7955)
  • sm (7227)
  • AgaP_AGAP012054 (7165)
  • C44B7.2 (6239)

  • Inparanoids
  • FBpp0085681 (7227)
  • ENSMUSP00000096222 (10090)
  • ENSRNOP00000053867 (10116)
  • ENSMMUP00000006484 (9544)
  • ENSP00000221419 (9606)



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