Sin3A

Symbol: Sin3A
Alias: CG8815-PA;CG8815-PB;CG8815-PC;CG8815-PD;CG8815-PE;CG8815-PF;Sin3A-PA;Sin3A-PB;Sin3A-PC;Sin3A-PD;Sin3A-PE;Sin3A-PF;enhancerofGMR-sina2-3
Entrez gene ID: 36382
Ensembl gene ID: FBgn0022764
Species: Fly (Taxid: 7227)

Functional description:
Scoffolding protein that complexes with histone deacteylases (HDAC1/2) where it interacts with corepressors to control transcriptional silencing of genes; CG8815 gene product from transcript CG8815-RC; Sin3A [Source:FlyBase gene name;Acc:FBgn0022764] [Ensembl]; The gene Sin3A is referred to in FlyBase by the symbol Dmel\Sin3A (CG8815, FBgn0022764). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; neuron development; regulation of mitotic cell cycle; muscle organ development; negative regulation of transcription, DNA-dependent. 60 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; mesothoracic tergum; mitochondrion; crystal cell. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Histone deacetylase interacting; Paired amphipathic helix. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [FlyBase]

Observation:

Overexpression of Sin3A increases mean and maximum lifespan by 13% and 3%, respectively [22366109].



Interventions:
  • Sin3A overexpression +13% +3%

  • Assays: Organismal Lifespan
    Mean: +13
    Maximum: +3

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • SIN3A (9606)
  • SIN3A (9598)
  • SIN3A (9615)
  • SIN3A (9913)
  • Sin3a (10090)
  • Sin3a (10116)
  • SIN3A (9031)
  • sin3aa (7955)
  • sin3ab (7955)
  • Sin3A (7227)
  • AgaP_AGAP007892 (7165)
  • pst1 (4896)
  • SIN3 (4932)
  • KLLA0C06182g (28985)
  • AGOS_ACL004W (33169)
  • GeneID:2676945 (148305)
  • NCU02578 (5141)

  • Inparanoids
  • FBpp0087000 (7227)
  • ENSMUSP00000004494 (10090)
  • ENSRNOP00000043049 (10116)
  • ENSMMUP00000012160 (9544)
  • ENSP00000369131 (9606)
  • SPBC12C2.10c (4896)



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