Denigma

UBP6

Symbol: UBP6
Name: UBiquitin-specific Protease 6
Entrez gene ID: 850562
Ensembl gene ID: YFR010W
Species: Yeast (Taxid: 4932)

Functional description:
Ubp6p; Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001906] [Ensembl]

Observation:

Deletion of UBP6 decreases mean (-32%) and maximum (-39%) replicative lifespan [21931558].



Assays:
Mean: -32
Maximum: -39

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • USP14 (9606)
  • USP14 (9598)
  • USP14 (9615)
  • USP14 (9913)
  • Usp14 (10090)
  • Usp14 (10116)
  • USP14 (9031)
  • usp14 (7955)
  • CG5384 (7227)
  • AgaP_AGAP009348 (7165)
  • usp-14 (6239)
  • ubp6 (4896)
  • UBP6 (4932)
  • KLLA0A10791g (28985)
  • GeneID:2682523 (148305)
  • NCU01919 (5141)
  • UBP6 (3702)
  • UBP7 (3702)
  • Os01g0550100 (4530)



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