RPN4

Symbol: RPN4
Name: Regulatory Particle Non-ATPase 4
Alias: SON1;UFD5
Entrez gene ID: 851542
Ensembl gene ID: YDL020C
Species: Yeast (Taxid: 4932)

Functional description:
Rpn4p; Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses [Source:SGD;Acc:S000002178] [Ensembl]

Observation:

Deletion mutants of the C2H2 zinc-finger transcription factor RPN4, are characterized by a reduced non-adaptable proteasome pool and display a 37 - 53% and 22-33% reduction in mean and maximum replicative lifespan. TOR1 deletion extends rpn4 replicative lifespan. Severe DR by reducing glucose concentration to 0.05% increased replicative lifespan of rpn4 mutants. RPN4 transcription is controlled by HSF1 [21931558].



Assays:
Mean: -37-53
Maximum: -22-33

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • RPN4 (4932)
  • KLLA0C04103g (28985)
  • AGOS_AER227W (33169)



  • Edit \ Update (Admin) | Delete

    Comment on This Data Unit