KES1

Symbol: KES1
Name: KrE11-1 Suppressor
Alias: OSH4
Entrez gene ID: 855958
Ensembl gene ID: YPL145C
Species: Yeast (Taxid: 4932)

Functional description:
Kes1p; Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex [Source:SGD;Acc:S000006066] [Ensembl]

Observation:

Deletion of OSH4 decreases mean replicative lifespan by 18% [Xia et al., unpublished].



Interventions:
  • OSH4 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • kes1 (4896)
  • SPBC354.07c (4896)
  • HES1 (4932)
  • KES1 (4932)
  • KLLA0D07480g (28985)
  • AGOS_ACR125W (33169)
  • GeneID:2675904 (148305)
  • NCU08578 (5141)



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