Symbol: SRX1 Name: SulfiRedoXin 1 Entrez gene ID: 853776 Ensembl gene ID: YKL086W Species: Yeast (Taxid: 4932) Functional description: Srx1p; Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes [Source:SGD;Acc:S000001569] [Ensembl] Observation: Extra copy of SRX1 counteracts age-related hyperoxidation of Tsa1 and extends replicative lifespan by 15 - 20% in a TSA1-dependent manner. Replicative lifespan extension in sir2;fob1 double mutant by DR is reduced by SRX1 deletion. Wild-type cells require SRX1 to fully extend lifespan. DR fails to further extend replicative lifespan of cells carrying an extra copy of SRX1. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on SRX1 to extend replicative lifespan [21884982]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source: Homologs Edit \ Update (Admin) | Delete |
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