Coq7

Symbol: Coq7
Name: demethyl-Q 7
Alias: mclk1; clk-1
Entrez gene ID: 12850
Ensembl gene ID: ENSMUSG00000030652
Species: Mouse (Taxid: 10090)

Functional description:
Involved in lifespan determination in ubiquinone- independent manner. Involved in ubiquinone biosynthesis. Potential central metabolic regulator. [UniProt]

Observation:

Mice heterozygous in Coq7 live about 15 to 30% longer than controls [16195414]. Transgenic overexpression of mouse Coq7 reverts the extended lifespan of clk-1 mutants in C. elegans [11511092].



Interventions:
  • Coq7 overexpression
  • Coq7 knockout +15 to +30%

  • Assays: Organismal Lifespan
    Mean: +15 to +30

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • References:
  • 11511092: Mouse coq7/clk-1 orthologue rescued slowed rhythmic behavior and extended life span of clk-1 longevity mutant in Caenorhabditis elegans.
  • 16195414: Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • COQ7 (9606)
  • COQ7 (9598)
  • COQ7 (9615)
  • COQ7 (9913)
  • Coq7 (10090)
  • Coq7 (10116)
  • COQ7 (9031)
  • zgc:158731 (7955)
  • COQ7 (7227)
  • clk-1 (6239)
  • coq7 (4896)
  • CAT5 (4932)
  • KLLA0E02421g (28985)
  • AGOS_ACL162C (33169)
  • GeneID:2674104 (148305)
  • NCU03957 (5141)

  • Orthologs
  • clk-1 (6239)
  • clk-1 (6239)



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