Denigma

lsd-1

Symbol: lsd-1
Name: Lysine-Specific histone Demethylase homolog
Entrez gene ID: 181369
Ensembl gene ID: T08D10.2
Species: Worm (Taxid: 6239)

Functional description:
Protein LSD-1; Lysine-Specific histone Demethylase homolog family member (lsd-1) [Source:RefSeq peptide;Acc:NP_510000] [Ensembl]; T08D10.2 encodes an ortholog of the human histone demethylase LSD1 (KIAA0601), and a paralog of C. elegans SPR-5; similar histone demethylase homologs are found in human, mouse, Drosophila, fission yeast, and Arabidopsis; T08D10.2 is predicted to demethylate histone H3 lysine 4 residues and act as a transcriptional corepressor. [WormBase]

Observation:

T08D10.2 RNAi is extend median longevity by 28% [17959600].



Assays:

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • KDM1A (9606)
  • KDM1A (9598)
  • KDM1A (9615)
  • KDM1A (9913)
  • Kdm1a (10090)
  • Kdm1 (10116)
  • AOF2 (9031)
  • kdm1a (7955)
  • Su(var)3-3 (7227)
  • AgaP_AGAP011661 (7165)
  • spr-5 (6239)
  • lsd-1 (6239)
  • lsd1 (4896)
  • lsd2 (4896)
  • GeneID:2680885 (148305)
  • NCU09120 (5141)
  • LDL1 (3702)
  • Os02g0755200 (4530)



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