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Symbol: TCO89 Name: Tor Complex One Entrez gene ID: 855922 Ensembl gene ID: YPL180W Species: Yeast (Taxid: 4932) Functional description: Tco89p; Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin [Source:SGD;Acc:S000006101] [Ensembl] Observation: TCO89 deletion increases chronological lifespan, increases mitochondrial oxygen consumption, but decreases mitochondrial and cellular ROS in early stationary phase [21641548]. Deletion of TCO89 cancels out replicative lifespan extension by moderate DR [18690010]. Interventions: Assays: Replicative Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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