MRPL25

Symbol: MRPL25
Name: Mitochondrial Ribosomal Protein, Large subunit 25
Alias: AFO1;YMR26;YmL25
Entrez gene ID: 852967
Ensembl gene ID: YGR076C
Species: Yeast (Taxid: 4932)

Functional description:
Mrpl25p; Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003308] [Ensembl]

Observation:

MRPL25/AFO1 (aging factor one) deletion confers increase in mean and maximum replicative lifespan by 60% and 40%, respectively. AFO1 encodes a protein that is contained in the large subunit of the mitochondrial ribososme. Lifespan extension by afo1 is independent of mitochondrial translation and formation of extrachromosomal ribosomal-DNA circles, but involves cytoplasmic Tor1 as well as Sfp1 [20157544].



Assays:
Mean: +60
Maximum: +40

Classification:

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • MRPL25 (4932)
  • KLLA0D03817g (28985)
  • AGOS_AER207C (33169)



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