ZTA1

Symbol: ZTA1
Name: Zeta-crystallin homolog, found in the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin, which has quinone oxidoreductase activity
Entrez gene ID: 852335
Species: Yeast (Taxid: 4932)

Functional description:
Zta1p; NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin [Source:SGD;Acc:S000000250] [Ensembl]

Observation:

Deletion of ZTA1 increases replicative lifespan by 15% in the alpha strain and decreased by 10% in the a strain [18340043]. Although ZTA1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of ZTA1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825].



Interventions:
  • ZTA1 deletion

  • Assays: Replicative Lifespan

    Classification:
  • Aging Associated


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • LOC100332654 (7955)
  • ZTA1 (4932)
  • KLLA0A10549g (28985)
  • AGOS_ABL090W (33169)
  • GeneID:2684741 (148305)
  • NCU04443 (5141)
  • AT5G61510 (3702)
  • Os03g0101600 (4530)
  • Os10g0561100 (4530)



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