cm

Symbol: cm
Name: carmine
Entrez gene ID: 31647
Ensembl gene ID: FBgn0000330
Species: Fly (Taxid: 7227)

Functional description:
u-subunit of AP-3 complex; carmine; carmine [Source:FlyBase gene name;Acc:FBgn0000330] [Ensembl]; The gene carmine is referred to in FlyBase by the symbol Dmel\cm (CG3035, FBgn0000330). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; regulation of alternative nuclear mRNA splicing, via spliceosome; ommochrome biosynthetic process; neurogenesis. 15 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; mesothoracic tergum; rhabdomere; eye; wing; secondary pigment cell pigment granule; tertiary pigment cell pigment granule; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Clathrin adaptor, mu subunit; Clathrin adaptor, mu subunit, C-terminal; Clathrin adaptor, mu subunit, conserved site; Longin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during early pupal stages, in adult female stages. [FlyBase]

Observation:

Loss-of-function mutation in cm reduces mean lifespan by 43 - 53% and maximum lifespan by 40 - 44% [17435236].



Interventions:
  • cm mutation -43 to -53% -40 to -44%

  • Assays: Organismal Lifespan
    Mean: -43 to -53
    Maximum: -40 to -44

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • References:
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • AP3M2 (9606)
  • AP3M2 (9598)
  • AP3M2 (9615)
  • AP3M2 (9913)
  • Ap3m2 (10090)
  • Ap3m2 (10116)
  • AP3M2 (9031)
  • ap3m2 (7955)
  • cm (7227)
  • AgaP_AGAP001484 (7165)
  • AT1G56590 (3702)
  • Os05g0383100 (4530)

  • Inparanoids
  • FBpp0070992 (7227)
  • ENSMUSP00000022371 (10090)
  • ENSRNOP00000025675 (10116)
  • ENSMMUP00000027410 (9544)
  • ENSP00000174653 (9606)



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