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Symbol: CLN3 Name: CycLiN 3 Alias: WHI1; FUN10; DAF1 Entrez gene ID: 851191 Ensembl gene ID: YAL040C Species: Yeast (Taxid: 4932) Functional description: Cln3p; G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis [Source:SGD;Acc:S000000038] [Ensembl] Observation: Overexpression shortens chronological lifespan together with age-dependent increases in genome instability and apoptosis. While around 80% of wild-type cells are alive almost non CLN3 overexpressers are alive (under condition that avoids adaptive regrowth) [17710147]. Interventions: Assays: Chronological Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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