Denigma: Factor

YME1

Symbol: YME1
Name: Yeast Mitochondrial Escape 1
Entrez gene ID: 856135
Ensembl gene ID: YPR024W
Species: Yeast (Taxid: 4932)

Functional description:
Yme1p; Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover [Source:SGD;Acc:S000006228] [Ensembl]

Observation:

Deletion of YME1 decreases chronological lifespan by 50% [17492370] as well as replicative lifespan by 45% in the alpha strain [18340043].

Interventions:

YME1 deletion -45 to -50%

Assays: Replicative Lifespan Chronological Lifespan

Classification:

Aging-Suppressor

Negative Aging-Suppressor

Aging Relevance Analysis/Source:

GenAge