YHC3

Symbol: YHC3
Name: Yeast Homolog of human Cln3
Alias: BTN1
Entrez gene ID: 853387
Ensembl gene ID: YJL059W
Species: Yeast (Taxid: 4932)

Functional description:
Yhc3p; Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) [Source:SGD;Acc:S000003595] [Ensembl]

Observation:

YHC3 deletion decreases 10-20% shortened lifespan [16435200].



Interventions:
  • YHC3 deletion -10 to -20%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CLN3 (9606)
  • CLN3 (9615)
  • Cln3 (10090)
  • Cln3 (10116)
  • zgc:92244 (7955)
  • cln3 (7227)
  • AgaP_AGAP003934 (7165)
  • cln-3.2 (6239)
  • cln-3.3 (6239)
  • cln-3.1 (6239)
  • btn1 (4896)
  • YHC3 (4932)
  • KLLA0F01551g (28985)
  • AGOS_AEL171C (33169)
  • GeneID:2684759 (148305)
  • NCU08408 (5141)
  • NCU10272 (5141)

  • Note: Is it really a yeast gene? Does it effect chronological or replicative (was just assumed) lifespan?

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