Denigma

INM2

Symbol: INM2
Name: INositol Monophosphatase 2
Entrez gene ID: 851881
Ensembl gene ID: YDR287W
Species: Yeast (Taxid: 4932)

Functional description:
Inm2p; Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy [Source:SGD;Acc:S000002695] [Ensembl]

Observation:

Deletion of INM2 decreases replicative lifespan by 70% in the alpha strain [19030232].



Interventions:
  • INM2 deletion -70%

    • Assays: Organismal Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • IMPA1 (9606)
  • IMPA1 (9598)
  • IMPA1 (9615)
  • IMPA1 (9913)
  • Impa1 (10090)
  • Impa1 (10116)
  • IMPA1 (9031)
  • impa1 (7955)
  • CG9391 (7227)
  • AgaP_AGAP006570 (7165)
  • ttx-7 (6239)
  • INM1 (4932)
  • INM2 (4932)
  • GeneID:2684325 (148305)
  • NCU06348 (5141)
  • VTC4 (3702)
  • Os03g0587000 (4530)



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