MTC5

Symbol: MTC5
Name: Maintenance of Telomere Capping 5
Entrez gene ID: 851706
Ensembl gene ID: YDR128W
Species: Yeast (Taxid: 4932)

Functional description:
expression is strongly induced by alpha factor; Mtc5p; Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000002535] [Ensembl]

Observation:

Deletion of MTC5 decreases replicative lifespan by 35% in the alpha strain [19030232].



Interventions:
  • MTC5 deletion -35%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • WDR59 (9606)
  • WDR59 (9598)
  • WDR59 (9615)
  • WDR59 (9913)
  • Wdr59 (10090)
  • WDR59 (9031)
  • LOC100000060 (7955)
  • CG4705 (7227)
  • AgaP_AGAP008331 (7165)
  • SPAC11E3.05 (4896)
  • MTC5 (4932)
  • KLLA0F19734g (28985)
  • AGOS_AGR067W (33169)



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