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Symbol: TOP1 Name: Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination Entrez gene ID: 854156 Species: Yeast (Taxid: 4932) Functional description: Top1p; Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination [Source:SGD;Acc:S000005366] [Ensembl] Observation: Replicative lifespan decreased by 60% in the alpha strain Assays: Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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