cher

Symbol: cher
Name: cheerio
Entrez gene ID: 42066
Ensembl gene ID: FBgn0014141
Species: Fly (Taxid: 7227)

Functional description:
cheerio; cheerio [Source:FlyBase gene name;Acc:FBgn0014141] [Ensembl]; The gene cheerio is referred to in FlyBase by the symbol Dmel\cher (CG3937, FBgn0014141). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence for 11 unique biological process terms, many of which group under: cellular component organization or biogenesis; localization; germline ring canal formation; learning or memory; ovarian nurse cell to oocyte transport; system process; cognition; germarium-derived female germ-line cyst encapsulation; multicellular organismal development; associative learning; biological regulation; determination of adult lifespan; multicellular organism reproduction. 32 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; anatomical structure; portion of tissue; epithelial cell; ovariole; nurse cell ring canal; interfollicle cell; nurse cell; germarium. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Actinin-type, actin-binding, conserved site; Calponin homology domain; Filamin/ABP280 repeat; Filamin/ABP280 repeat-like; Immunoglobulin E-set; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during late pupal stages. [FlyBase]

Observation:

Overexpression of cher from a doxycycline-inducible promoter results in a 7 - 9% increase in mean lifespan (in PdL x rtTA; Oregon-R x rtTA) [12620118].



Interventions:
  • cher overexpression +7 to +9%

  • Assays: Organismal Lifespan
    Mean: +7 to +9

    Classification:
  • Aging-Suppressor
  • Positive Aging-Suppressor


  • References:
  • 12620118: A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • FLNA (9606)
  • FLNA (9615)
  • FLNA (9913)
  • Flna (10090)
  • Flna (10116)
  • flna (7955)
  • cher (7227)
  • AgaP_AGAP004335 (7165)
  • Y66H1B.2 (6239)

  • Inparanoids
  • ENSMUSP00000033699 (10090)
  • ENSRNOP00000008910 (10116)
  • ENSMMUP00000017986 (9544)
  • ENSP00000358879 (9606)



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