Symbol: cher Name: cheerio Entrez gene ID: 42066 Ensembl gene ID: FBgn0014141 Species: Fly (Taxid: 7227) Functional description: cheerio; cheerio [Source:FlyBase gene name;Acc:FBgn0014141] [Ensembl]; The gene cheerio is referred to in FlyBase by the symbol Dmel\cher (CG3937, FBgn0014141). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: actin binding. There is experimental evidence for 11 unique biological process terms, many of which group under: cellular component organization or biogenesis; localization; germline ring canal formation; learning or memory; ovarian nurse cell to oocyte transport; system process; cognition; germarium-derived female germ-line cyst encapsulation; multicellular organismal development; associative learning; biological regulation; determination of adult lifespan; multicellular organism reproduction. 32 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; anatomical structure; portion of tissue; epithelial cell; ovariole; nurse cell ring canal; interfollicle cell; nurse cell; germarium. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Actinin-type, actin-binding, conserved site; Calponin homology domain; Filamin/ABP280 repeat; Filamin/ABP280 repeat-like; Immunoglobulin E-set; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 12-18 embryonic stages, during late larval stages, during late pupal stages. [FlyBase] Observation: Overexpression of cher from a doxycycline-inducible promoter results in a 7 - 9% increase in mean lifespan (in PdL x rtTA; Oregon-R x rtTA) [12620118]. Interventions: Assays: Organismal Lifespan Mean: +7 to +9 Classification: References: Aging Relevance Analysis/Source: Homologs Inparanoids Edit \ Update (Admin) | Delete |
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